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Ian M Adcock Selected Research

Theophylline (Theon)

5/2014Impact of theophylline/corticosteroid combination therapy on sputum hydrogen sulfide levels in patients with COPD.
3/2014Sputum myeloperoxidase in chronic obstructive pulmonary disease.
7/2012Corticosteroid resistance and novel anti-inflammatory therapies in chronic obstructive pulmonary disease: current evidence and future direction.
10/2010Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.
6/2010Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD.
12/2005Histone deacetylation: an important mechanism in inflammatory lung diseases.
9/2004Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.
6/2002A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.

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Ian M Adcock Research Topics

Disease

128Asthma (Bronchial Asthma)
01/2022 - 03/2002
107Chronic Obstructive Pulmonary Disease (COPD)
07/2022 - 01/2002
82Inflammation (Inflammations)
07/2022 - 09/2002
18Infections
02/2022 - 07/2005
15Respiratory Hypersensitivity
01/2022 - 07/2007
15Neoplasms (Cancer)
01/2021 - 11/2006
13Airway Remodeling
07/2022 - 01/2004
13Respiratory Tract Diseases (Respiratory Tract Disease)
01/2022 - 01/2006
13Pneumonia (Pneumonitis)
01/2022 - 05/2005
13Lung Diseases (Lung Disease)
06/2020 - 12/2005
12Lung Neoplasms (Lung Cancer)
01/2021 - 10/2010
10Eosinophilia
01/2019 - 09/2002
9Tuberculosis (Tuberculoses)
11/2020 - 12/2016
9Sarcoidosis (Schaumann Disease)
04/2018 - 10/2014
8COVID-19
02/2022 - 01/2020
7Emphysema
07/2022 - 01/2014
7Fibrosis (Cirrhosis)
07/2022 - 01/2018
6Necrosis
01/2017 - 07/2004
5Virus Diseases (Viral Diseases)
01/2022 - 01/2006
5Cystic Fibrosis (Mucoviscidosis)
01/2019 - 05/2005
4Mitochondrial Diseases (Mitochondrial Disease)
01/2022 - 09/2015
4Familial Primary Pulmonary Hypertension
11/2019 - 01/2013
4Melanoma (Melanoma, Malignant)
01/2018 - 04/2011
4Pulmonary Arterial Hypertension
01/2017 - 09/2009
4Heart Failure
08/2005 - 08/2002
3Hypersensitivity (Allergy)
01/2021 - 08/2016
3Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
11/2019 - 01/2011
3Wounds and Injuries (Trauma)
01/2019 - 01/2002
3Porcine Reproductive and Respiratory Syndrome (PRRS)
08/2017 - 01/2015
3Hypoxia (Hypoxemia)
06/2015 - 07/2007

Drug/Important Bio-Agent (IBA)

57Adrenal Cortex Hormones (Corticosteroids)IBA
01/2022 - 01/2002
43Biomarkers (Surrogate Marker)IBA
06/2022 - 04/2010
35Proteins (Proteins, Gene)FDA Link
07/2022 - 08/2002
31CytokinesIBA
06/2022 - 11/2003
31GlucocorticoidsIBA
01/2022 - 04/2002
28SteroidsIBA
01/2022 - 04/2002
23SmokeIBA
07/2022 - 01/2004
16MicroRNAs (MicroRNA)IBA
01/2021 - 06/2009
15Transcription Factors (Transcription Factor)IBA
01/2019 - 01/2002
14Messenger RNA (mRNA)IBA
07/2022 - 07/2004
14Interleukin-8 (Interleukin 8)IBA
04/2021 - 09/2004
14OzoneIBA
07/2019 - 07/2007
13Histones (Histone)IBA
01/2021 - 01/2002
12AntioxidantsIBA
07/2022 - 01/2005
12Phosphotransferases (Kinase)IBA
06/2022 - 01/2004
12Dexamethasone (Maxidex)FDA LinkGeneric
02/2022 - 04/2002
11InflammasomesIBA
01/2022 - 01/2012
11Toll-Like Receptors (Toll-Like Receptor)IBA
12/2021 - 10/2007
11Interleukin-6 (Interleukin 6)IBA
04/2021 - 06/2013
11DNA (Deoxyribonucleic Acid)IBA
06/2020 - 01/2002
10Oxidants (Oxidizing Agents)IBA
06/2022 - 01/2005
10Immunoglobulin E (IgE)IBA
01/2022 - 06/2003
10Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2021 - 09/2002
10Pharmaceutical PreparationsIBA
01/2021 - 09/2004
10NF-kappa B (NF-kB)IBA
01/2017 - 12/2005
9Biological ProductsIBA
06/2022 - 11/2013
8Interleukin-13IBA
01/2022 - 01/2012
8Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
04/2021 - 08/2002
8InterferonsIBA
04/2021 - 04/2011
8Theophylline (Theon)FDA LinkGeneric
05/2014 - 06/2002
7ChemokinesIBA
06/2022 - 11/2003
7EnzymesIBA
12/2021 - 08/2004
7Fluticasone (Cutivate)FDA LinkGeneric
12/2017 - 01/2004
7p38 Mitogen-Activated Protein KinasesIBA
06/2013 - 04/2002
7Histone Deacetylases (Histone Deacetylase)IBA
08/2010 - 02/2004
6Reactive Oxygen Species (Oxygen Radicals)IBA
07/2022 - 05/2014
6RNA (Ribonucleic Acid)IBA
12/2021 - 12/2016
6Transforming Growth Factors (Transforming Growth Factor)IBA
01/2021 - 05/2011
6InterleukinsIBA
01/2020 - 03/2002
5Bronchodilator Agents (Bronchodilators)IBA
01/2022 - 07/2012
5Antiviral Agents (Antivirals)IBA
04/2021 - 01/2019
5Interleukin-17 (Interleukin 17)IBA
11/2019 - 09/2012
5Interleukin-4 (Interleukin 4)IBA
01/2019 - 07/2004
5AntigensIBA
08/2017 - 10/2014
5Salmeterol Xinafoate (Serevent)FDA Link
01/2016 - 01/2004
5Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
12/2015 - 07/2011
5LipopolysaccharidesIBA
01/2015 - 04/2005
5Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
11/2013 - 04/2002
5AllergensIBA
03/2012 - 09/2002
4AutoantibodiesIBA
07/2022 - 10/2011
4Interleukin-5 (Interleukin 5)IBA
01/2022 - 07/2004
4Particulate MatterIBA
07/2021 - 01/2019
4LigandsIBA
10/2019 - 06/2004
4PeriostinIBA
01/2019 - 06/2012
4NLR ProteinsIBA
01/2018 - 01/2015
4Interleukin-10 (Interleukin 10)IBA
11/2015 - 03/2002
4JNK Mitogen-Activated Protein KinasesIBA
11/2013 - 12/2003
4Histone Acetyltransferases (Histone Acetyltransferase)IBA
08/2010 - 02/2003
4pyrazolanthroneIBA
07/2007 - 12/2003
3Prednisolone (Predate)FDA LinkGeneric
01/2021 - 09/2003
3IronIBA
01/2020 - 04/2016
3Interleukin-33IBA
01/2019 - 08/2014
3Budesonide (Pulmicort)FDA LinkGeneric
01/2018 - 07/2007
3NucleotidesIBA
01/2018 - 01/2017
3Pattern Recognition ReceptorsIBA
08/2017 - 01/2015
3Monoclonal AntibodiesIBA
05/2015 - 09/2008
3Mitogen-Activated Protein KinasesIBA
01/2015 - 01/2005

Therapy/Procedure

68Therapeutics
06/2022 - 06/2002
4Drug Therapy (Chemotherapy)
01/2019 - 10/2010
3Aftercare (After-Treatment)
01/2016 - 02/2008